Endocrine Abstracts

Introduction: Effects on fertility have been seen as important late effects of treatment for childhood cancer.Aim: To evaluate the impact of chemotherapy and radiotherapy treatment for childhood medulloblastoma on gonadal function.Methods: Retrospective cohort study of all children treated for medulloblastoma (diagnosed from 2–18 years) in a single institution in the UK between 1983–2011 and a minimum relapse-free surviva...

Hypospadias is among the most common congenital malformations with a mean prevalence of 19.9 per 10,000 live births in Europe. The cause of many cases of hypospadias remains unclear but likely results from a combination of genetic susceptibility and environmental factors. Although rodent studies have provided great insights into external genitalia morphogenesis, extrapolations to the human genitals is challenging given significant anatomic and morphogenetic differences. With t...